Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study

Acta Gastroenterol Belg. Jan-Mar 2019;82(1):27-30.


Aim: This study evaluates hepatitis B virus (HBV) vaccination response in children with celiac disease (CD). Response in initial non-responders after a single booster vaccination as well as factors influencing HBV vaccination response were evaluated.

Methodology: Anti-hepatitis B surface antibodies (a-HBsAB) were checked in all children with CD and a documented complete HBV vaccination. An a-HBsAB <10 U/L was considered as non-response. A single intramuscular HBV-vaccine booster was advised to all non-responders. Response was checked at the next appointment.

Results: 133 children with CD were included, median age of 7.3 years (range 1.7-17.3) and 46 (35%) were male. The age at CD diagnosis was 6.0 years (range 1.1-15.7). HBV non-response was documented in 55% (n=73/133). No other factors were influencing the response. A booster was documented in 34/73 (47 %) initial non-responders (3 refused (4%), 36 (49%) had no follow up). Response after booster vaccination resulted in immunity in 22/34 (65%) and persisting non-response in 12/34 (35%). A single booster is able to reduce non-response from 55% (73/133) to 23% (22/94).

Conclusion: A significantly lower immune response following HBV vaccination in children with CD was confirmed. A single intramuscular booster vaccination is able to induce a serologic response in two thirds of the initial non-responders. Control of HBV vaccination response has to become part of the follow-up in CD patients.

Keywords: celiac disease; children; hepatitis B; intradermal; vaccination.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Celiac Disease* / blood
  • Celiac Disease* / complications
  • Celiac Disease* / immunology
  • Child
  • Child, Preschool
  • Hepatitis B / complications
  • Hepatitis B / immunology
  • Hepatitis B / prevention & control*
  • Hepatitis B Antibodies / analysis
  • Hepatitis B Antibodies / blood
  • Hepatitis B Surface Antigens / metabolism
  • Hepatitis B Surface Antigens / therapeutic use
  • Hepatitis B Vaccines / administration & dosage*
  • Hepatitis B Vaccines / metabolism
  • Hepatitis B Vaccines / therapeutic use
  • Hepatitis B virus
  • Humans
  • Immunity, Active / drug effects
  • Immunization, Secondary
  • Immunocompromised Host / drug effects
  • Infant
  • Male
  • Prospective Studies
  • Vaccination / statistics & numerical data*


  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines