Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death

Cell Calcium. 2019 May:79:89-97. doi: 10.1016/j.ceca.2019.02.006. Epub 2019 Feb 16.


Physiological signaling by reactive oxygen species (ROS) and their pathophysiological role in cell death are well recognized. This review focuses on two ROS targets that are key to local Ca2+ signaling at the ER/mitochondrial interface - notably, inositol trisphosphate receptors (IP3Rs) and the mitochondrial calcium uniporter (MCU). Both transport systems are central to molecular mechanisms in cell survival and death. Methods for the measurement of the redox state of these proteins and for the detection of ROS nanodomains are described. Recent results on the redox regulation of these proteins are reviewed.

Keywords: Ca(2+); IP(3); IP(3) receptor; Mitochondrial calcium uniporter; Reactive oxygen species; Redox regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling*
  • Cell Death
  • Cell Survival
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Mitochondria / chemistry
  • Mitochondria / metabolism*
  • Oxidation-Reduction


  • Calcium