Clinical utility of SUDOSCAN in predicting autonomic neuropathy in patients with Parkinson's disease

Parkinsonism Relat Disord. 2019 Jul;64:60-65. doi: 10.1016/j.parkreldis.2019.03.007. Epub 2019 Mar 15.

Abstract

Introduction: Autonomic neuropathy is common in Parkinson's disease (PD). We evaluated whether SUDOSCAN, a novel electrophysiological device that provides a simple and quantitative assessment of sudomotor function, was able to detect PD-related autonomic neuropathy. We also used the device to examine potential risk factors for PD-related autonomic neuropathy.

Methods: Forty-three hospitalized patients in the later stages of PD underwent assessments including a clinical history, the Unified Parkinson's Disease Rating Scale (UPDRS), the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT), and measurement of homocysteine (HCY) and vitamin B12 levels. Sudomotor function was assessed by measuring electrochemical skin conductance (ESC) using SUDOSCAN. Forty-two healthy participants served as controls.

Results: ESC of the limbs, and especially the hands, was significantly lower in PD patients than in controls and was significantly correlated with SCOPA-AUT results. ESC was strongly negatively correlated with PD duration. The results also indicated that levodopa exposure and a higher HCY level may be risk factors for PD-related autonomic neuropathy.

Conclusions: SUDOSCAN was able to effectively identify autonomic neuropathy in PD patients. ESC was decreased in PD patients and was correlated with PD-related autonomic symptoms. These findings suggest that SUDOSCAN could be a promising new method for assessing PD-related autonomic neuropathy.

Keywords: Autonomic neuropathy; Homocysteine; Levodopa; Parkinson's disease; Sudomotor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antiparkinson Agents / therapeutic use
  • Autonomic Nervous System Diseases / diagnosis*
  • Autonomic Nervous System Diseases / etiology*
  • Electrophysiology / instrumentation*
  • Female
  • Galvanic Skin Response / physiology*
  • Homocysteine / blood
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Parkinson Disease / blood
  • Parkinson Disease / complications*
  • Parkinson Disease / drug therapy

Substances

  • Antiparkinson Agents
  • Homocysteine
  • Levodopa