Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders

Simone Brogi; Giuseppe Campiani; Margherita Brindisi; Stefania Butini

doi:10.1021/acsmedchemlett.8b00450

Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders

ACS Med Chem Lett. 2019 Jan 23;10(3):228-236. doi: 10.1021/acsmedchemlett.8b00450. eCollection 2019 Mar 14.

Authors

Simone Brogi^{1

2}, Giuseppe Campiani¹, Margherita Brindisi¹, Stefania Butini¹

Affiliations

¹ Department of Biotechnology, Chemistry and Pharmacy, University of Siena, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100 Siena, Italy.
² Department of Pharmacy, University of Napoli Federico II, DoE Department of Excellence 2018-2022, Via D. Montesano 49, 80131 Napoli, Italy.

Abstract

The allosteric targeting of ionotropic glutamate receptors (iGluRs) is a valuable approach for treating various central nervous system (CNS) disorders. In this frame, this Innovations provides a summary of the state-of-the art in the development of allosteric modulators for iGluRs and offers an outlook regarding innovative strategies for treating neurological diseases.