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Comparative Study
. 2019 Mar 20;14(3):e0213336.
doi: 10.1371/journal.pone.0213336. eCollection 2019.

Choroidal vascular index in patients with open angle glaucoma and preperimetric glaucoma

Yuli Park  1 , Kyong Jin Cho  1
Affiliations
Free PMC article
Comparative Study

Choroidal vascular index in patients with open angle glaucoma and preperimetric glaucoma

Yuli Park et al. PLoS One. .
Free PMC article

Abstract

Purpose: To evaluate choroidal structural changes in glaucoma using choroidal vascularity index (CVI) compared to healthy subjects.

Methods: This retrospective study included 56 patients with open angle glaucoma (OAG), 50 patients with preperimetric glaucoma (PPG) and 50 age-matched healthy eyes. Choroidal images were binarized into luminal area (LA) and stromal area. CVI was defined as the ratio of LA to total circumscribed choroid area (TCA). Mean choroidal thickness (CT) and mean CVI between glaucoma patients and healthy subjects were compared.

Results: OAG and PPG eyes showed smaller LA (0.45 ± 0.13 ㎟ vs. 0.47 ± 0.11 ㎟, p = 0.04). In multivariate regression analysis, CVI of both OAG (64.34±0.19%, p = 0.001) and PPG (65.37±0.15%, p = 0.001) were significantly lower than healthy eyes (68.81±0.14%).

Conclusion: Eyes with glaucoma demonstrated reduced CVI compared with healthy eyes. CVI may be a potential noninvasive tool for studying vascular dysfunction in glaucoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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Grants and funding

This study is supported by a grant of the National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF2016R1C1B2016649) to KJC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.