Clinical characteristics and glucose-lowering drug utilization among patients initiating liraglutide in Denmark: a routine clinical care prescription study

J Diabetes. 2019 Aug;11(8):690-694. doi: 10.1111/1753-0407.12919. Epub 2019 Apr 25.

Abstract

Highlights This population-based real-world prescription study characterized all new users of liraglutide in northern Denmark from 2009 to 2015. More than half (57%) the patients had liraglutide prescribed as part of drug combinations outside the originally approved indications. Comorbidities or diabetes complications were present in most patients, with the highest prevalence observed among the 73% of initiators who would have been ineligible for the Liraglutide Effect and Action in Diabetes (LEAD) 1-5 trials that led to liraglutide registration, underscoring the need for further post-marketing studies.

Keywords: cross-sectional studies; diabetes pharmacology; drug utilization; glucagon-like peptide-1 receptor; liraglutide.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers / metabolism
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Denmark
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Drug Utilization / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Glucose / metabolism*
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Infant
  • Infant, Newborn
  • Liraglutide / therapeutic use*
  • Male
  • Middle Aged
  • Practice Patterns, Physicians' / statistics & numerical data*
  • Prognosis
  • Young Adult

Substances

  • Biomarkers
  • Hypoglycemic Agents
  • Liraglutide
  • Glucose