Age-related AMP-activated protein kinase alterations: From cellular energetics to longevity

Cell Biochem Funct. 2019 Apr;37(3):169-176. doi: 10.1002/cbf.3384. Epub 2019 Mar 21.


5' adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of energy in the cell, which allows the cell/organism to survive with deficit of ATP. Since AMPK is involved in the adaptation to caloric restriction, the role of age-related changes in AMPK activity in both the aging organism and the aging cell is actively investigated in gerontology. Studies on yeast, worms, flies, rodents, and primates have demonstrated an important effect of this regulator on key signalling pathways involved in the aging process. In some cases, researchers conclude that AMPK promotes aging. However, in our opinion, in such cases, we observe a disturbance in the adaptive ability because of the prolonged cell/organism presence in stressful conditions because the functional capacity of any adaptation system is limited. Interestingly, AMPK can regulate metabolic processes in noncell-autonomous manner. The main effects of AMPK activation in the cell are realized in restriction of proliferation and launching autophagy. In tissues of an aging organism, the ability of AMPK to respond to energy deficit decreases; this fact is especially critical for organs that contain postmitotic cells. In this review, we have tried to consider the involvement of AMPK in age-related changes in the cell and in the organism.

Keywords: aging; caloric restriction; cell metabolism; cell proliferation; lifespan extension; stationary phase aging.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Aging / metabolism*
  • Animals
  • Energy Metabolism*
  • Humans
  • Longevity*


  • AMP-Activated Protein Kinases