This is the first article in a new series about evidence-based practice (EBP) that builds on AJN's award-winning previous series-Evidence-Based Practice, Step by Step-published between 2009 and 2011 (to access the series, go to http://links.lww.com/AJN/A133). This follow-up series will feature case studies illustrating the various strategies that can be used to implement EBP changes-one of the most challenging steps in the EBP process.