A hyaluronan/methylcellulose-based hydrogel for local cell and biomolecule delivery to the central nervous system

Brain Res Bull. 2019 May;148:46-54. doi: 10.1016/j.brainresbull.2019.03.005. Epub 2019 Mar 18.

Abstract

Regenerative medicine strategies rely on exogenous cell transplantation and/or endogenous cell stimulation. Biomaterials can help to increase the regenerative potential of cells and biomolecules by controlling transplanted cell fate and provide a local, sustained release of biomolecules. In this review, we describe the use of a hyaluronan/methylcellulose (HAMC)-based hydrogel as a delivery vehicle to the brain, spinal cord, and retina to promote cellular survival and tissue repair. We discuss various controlled release strategies to prolong the delivery of factors for neuroprotection. The versatility of this hydrogel for a diversity of applications highlights its potential to enhance cell- and biomolecule-based treatment strategies.

Keywords: Blindness; Cell delivery; Drug delivery; Hydrogel; Spinal cord injury; Stroke.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Brain / drug effects
  • Cell Survival
  • Central Nervous System / drug effects
  • Drug Delivery Systems / methods*
  • Humans
  • Hyaluronic Acid / pharmacology*
  • Hydrogels / pharmacology*
  • Methylcellulose / pharmacology*
  • Retina / drug effects
  • Spinal Cord / drug effects
  • Spinal Cord Injuries / drug therapy
  • Stem Cells

Substances

  • Biocompatible Materials
  • Hydrogels
  • Hyaluronic Acid
  • Methylcellulose

Grant support