High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma

Junjie Piao; Lianhua Zhu; Jie Sun; Nan Li; Bing Dong; Yang Yang; Liyan Chen

doi:10.1016/j.gene.2019.02.081

High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma

Gene. 2019 Jun 15:701:15-22. doi: 10.1016/j.gene.2019.02.081. Epub 2019 Mar 18.

Authors

Junjie Piao¹, Lianhua Zhu², Jie Sun³, Nan Li³, Bing Dong³, Yang Yang³, Liyan Chen⁴

Affiliations

¹ Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Key Laboratory of the Science and Technology Department of Jilin Province, Yanji 133002, China.
² Department of Dermatology, Yanbian University Hospital, Yanji 133000, China.
³ Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China.
⁴ Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Key Laboratory of the Science and Technology Department of Jilin Province, Yanji 133002, China. Electronic address: lychen@ybu.edu.cn.

PMID: 30898709
DOI: 10.1016/j.gene.2019.02.081

Abstract

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death. Increasing evidence suggests that cell cycle dysregulation is one of the hallmarks of cancer. In this study, by using the GEO database, we predicted the cell cycle-related protein CDK1 and BUB1 to be significantly overexpressed in PDAC tissues. Thus, this study aimed to investigate the clinical pathological significance of CDK1 and BUB1 in PDAC.

Methods: To explore the role of CDK1 and BUB1 in PDAC progression and evaluate their prognostic value, we investigated the expression patterns of CDK1 and BUB1 by using immunohistochemical staining in 99 PDAC and 71 normal pancreatic tissues with complete pathological parameters and survival data.

Results: CDK1 and BUB1 were significantly overexpressed in PDAC tissues. The expression of CDK1 was correlated with tumor size and histological grade, and the expression of BUB1 was correlated with the tumor size of PDAC. With regard to survival, a high expression of either CDK1 or BUB1 was correlated with a short survival of PDAC patients. Additionally, PDAC patients with a concurrent high expression of CDK1 and BUB1 showed the shortest survival.

Conclusions: Our study demonstrated that CDK1 and BUB1 may play a role in PDAC progression and could be prognostic biomarkers for PDAC patients.

Keywords: BUB1; CDK1; Immunohistochemistry; PDAC; Survival.

Publication types

Clinical Trial

MeSH terms

Biomarkers, Tumor / biosynthesis*
CDC2 Protein Kinase / biosynthesis*
Carcinoma, Pancreatic Ductal* / enzymology
Carcinoma, Pancreatic Ductal* / mortality
Carcinoma, Pancreatic Ductal* / pathology
Disease-Free Survival
Female
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Humans
Male
Neoplasm Proteins / biosynthesis*
Pancreatic Neoplasms* / enzymology
Pancreatic Neoplasms* / mortality
Pancreatic Neoplasms* / pathology
Predictive Value of Tests
Protein Serine-Threonine Kinases / biosynthesis*
Survival Rate

Substances

Biomarkers, Tumor
Neoplasm Proteins
BUB1 protein, human
Protein Serine-Threonine Kinases
CDC2 Protein Kinase
CDK1 protein, human