Acrylamide toxicity and cholinergic nervous system

J Physiol Pharmacol. 2018 Dec;69(6). doi: 10.26402/jpp.2018.6.03. Epub 2019 Mar 18.


Acrylamide (ACR) is a chemical compound, that forms in starchy food products during cooking at high-temperatures, including frying, baking, and roasting. ACR is a known lethal neurotoxin. The presented review suggests that the mechanism of ACR's neurotoxicity may be related to an impaired cholinergic transmission in the central and peripheral nervous system and redox imbalance. These may not only affect ongoing brain functions but also participate in etiology of neurodegeneration.

Publication types

  • Review

MeSH terms

  • Acrylamide / toxicity*
  • Animals
  • Cholinergic Agents / toxicity*
  • Humans
  • Nervous System / drug effects*
  • Neurotoxins / toxicity


  • Cholinergic Agents
  • Neurotoxins
  • Acrylamide