Non-acute promyelocytic leukemia variant, acute myeloid leukemia with translocation (11;17)

Clin Case Rep. 2019 Feb 10;7(3):558-563. doi: 10.1002/ccr3.2044. eCollection 2019 Mar.

Abstract

t(11;17) is a rare but recognized finding usually found in Acute Promyelocytic Leukemia with variant RARA translocation (APLv). We present a case of Acute Myeloid Leukemia with t(11;17) that has different break points than those occurring in APLv. The diagnosis of acute myeloid leukemia, not otherwise specified, acute monoblastic leukemia was reached after a thorough investigation. Reaching the correct diagnosis and distinguishing these two entities are essential as they have different management, prognosis, and overall survival.

Keywords: KMT2A/SEPT9; acute myeloid leukemia; acute promyelocytic leukemia; translocation t(11;17); variant RARA translocations.

Publication types

  • Case Reports