Clinical Application of Bone Turnover Markers in Osteoporosis in Korea

doi:10.11005/jbm.2019.26.1.19

Review

. 2019 Feb;26(1):19-24.

doi: 10.11005/jbm.2019.26.1.19. Epub 2019 Feb 28.

Clinical Application of Bone Turnover Markers in Osteoporosis in Korea

So Young Park¹, Seong Hee Ahn², Jun-Il Yoo³, Youn-Jee Chung⁴, Yun Kyung Jeon⁵, Byung-Ho Yoon⁶, Ha Young Kim⁷, Seung Hun Lee⁸, Jehoon Lee⁹, Seongbin Hong²

Affiliations

¹ Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
² Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
³ Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.
⁴ Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁵ Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
⁶ Department of Orthopaedic Surgery, Inje University College of Medicine, Seoul Paik Hospital, Seoul, Korea.
⁷ Division of Endocrinology, Department of Internal Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
⁸ Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
⁹ Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

PMID: 30899720
PMCID: PMC6416153
DOI: 10.11005/jbm.2019.26.1.19

Free PMC article

Review

Clinical Application of Bone Turnover Markers in Osteoporosis in Korea

So Young Park et al. J Bone Metab. 2019 Feb.

Free PMC article

. 2019 Feb;26(1):19-24.

doi: 10.11005/jbm.2019.26.1.19. Epub 2019 Feb 28.

Authors

So Young Park¹, Seong Hee Ahn², Jun-Il Yoo³, Youn-Jee Chung⁴, Yun Kyung Jeon⁵, Byung-Ho Yoon⁶, Ha Young Kim⁷, Seung Hun Lee⁸, Jehoon Lee⁹, Seongbin Hong²

Affiliations

¹ Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
² Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
³ Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.
⁴ Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁵ Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
⁶ Department of Orthopaedic Surgery, Inje University College of Medicine, Seoul Paik Hospital, Seoul, Korea.
⁷ Division of Endocrinology, Department of Internal Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
⁸ Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
⁹ Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

PMID: 30899720
PMCID: PMC6416153
DOI: 10.11005/jbm.2019.26.1.19

Abstract

Bone turnover markers (BTMs) have important role in the management of osteoporosis. Recently the clinical application of BTMs has achieved significant progress and measurement of BTMs give us better understanding of pathogenesis of osteoporosis. However, the use of BTMs is still insufficient in Korea. We summarized the available methods and standard interval of the BTMs in Korea. Also we reviewed published literatures on pre-analytical variability in the measurement of BTMs and provided recommendations for standardized sample handling and patient preparation for reducing those pre-analytical variabilities. The clinical application of BTMs in patients with chronic kidney disease who have a higher fracture risk than the general population is summarized.

Keywords: Biomarkers; Bone remodeling; Bone turnover markers; Chronic kidney disease; Osteoporosis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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References

1. Peck WA. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94:646–650. - PubMed
1. Weinstein RS. True strength. J Bone Miner Res. 2000;15:621–625. - PubMed
1. Blake GM, Fogelman I. Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom. 2007;10:102–110. - PubMed
1. Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 2010;285:25103–25108. - PMC - PubMed
1. Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121–145. - PMC - PubMed

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[1] Peck WA. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94:646–650. - PubMed

[2] Peck WA. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94:646–650. - PubMed

[3] Weinstein RS. True strength. J Bone Miner Res. 2000;15:621–625. - PubMed

[4] Weinstein RS. True strength. J Bone Miner Res. 2000;15:621–625. - PubMed

[5] Blake GM, Fogelman I. Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom. 2007;10:102–110. - PubMed

[6] Blake GM, Fogelman I. Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom. 2007;10:102–110. - PubMed

[7] Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 2010;285:25103–25108. - PMC - PubMed

[8] Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 2010;285:25103–25108. - PMC - PubMed

[9] Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121–145. - PMC - PubMed

[10] Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121–145. - PMC - PubMed

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Clinical Application of Bone Turnover Markers in Osteoporosis in Korea

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Clinical Application of Bone Turnover Markers in Osteoporosis in Korea

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