Abstract
Plipastatins are new inhibitors of phospholipase A2 produced by Bacillus cereus BMG302-fF67. Structures of the plipastatins have been determined by UV, mass and NMR spectrometries and chemical degradation. The carboxyl group of the C-terminal L-isoleucine of plipastatinic acid has been shown to form a lactone linkage with the hydroxyl group of L-tyrosine. The total structure of plipastatins has thus been established.
MeSH terms
-
Anti-Bacterial Agents* / biosynthesis
-
Anti-Bacterial Agents* / pharmacology
-
Bacillus cereus / metabolism
-
Chemical Phenomena
-
Chemistry
-
Fatty Acids* / analysis*
-
Lactones
-
Magnetic Resonance Spectroscopy
-
Oligopeptides* / analysis*
-
Peptides, Cyclic
-
Phospholipases / antagonists & inhibitors*
-
Phospholipases A / antagonists & inhibitors*
-
Phospholipases A2
-
Spectrophotometry, Infrared
-
Spectrophotometry, Ultraviolet
Substances
-
Anti-Bacterial Agents
-
Fatty Acids
-
Lactones
-
Oligopeptides
-
Peptides, Cyclic
-
plipastatin
-
Phospholipases
-
Phospholipases A
-
Phospholipases A2