Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. III. Structural elucidation of plipastatins

J Antibiot (Tokyo). 1986 Jun;39(6):755-61. doi: 10.7164/antibiotics.39.755.


Plipastatins are new inhibitors of phospholipase A2 produced by Bacillus cereus BMG302-fF67. Structures of the plipastatins have been determined by UV, mass and NMR spectrometries and chemical degradation. The carboxyl group of the C-terminal L-isoleucine of plipastatinic acid has been shown to form a lactone linkage with the hydroxyl group of L-tyrosine. The total structure of plipastatins has thus been established.

MeSH terms

  • Anti-Bacterial Agents* / biosynthesis
  • Anti-Bacterial Agents* / pharmacology
  • Bacillus cereus / metabolism
  • Chemical Phenomena
  • Chemistry
  • Fatty Acids* / analysis*
  • Lactones
  • Magnetic Resonance Spectroscopy
  • Oligopeptides* / analysis*
  • Peptides, Cyclic
  • Phospholipases / antagonists & inhibitors*
  • Phospholipases A / antagonists & inhibitors*
  • Phospholipases A2
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet


  • Anti-Bacterial Agents
  • Fatty Acids
  • Lactones
  • Oligopeptides
  • Peptides, Cyclic
  • plipastatin
  • Phospholipases
  • Phospholipases A
  • Phospholipases A2