Emerging roles of cytomegalovirus-encoded G protein-coupled receptors during lytic and latent infection

Med Microbiol Immunol. 2019 Aug;208(3-4):447-456. doi: 10.1007/s00430-019-00595-9. Epub 2019 Mar 21.


Cytomegaloviruses (CMVs) have developed multiple diverse strategies to ensure their replicative success and to evade immune recognition. Given the fact that G protein-coupled receptors (GPCRs) are key regulators of numerous cellular processes and modify a variety of signaling pathways, it is not surprising that CMVs and other herpesviruses have hijacked mammalian GPCRs during their coevolution. Human cytomegalovirus (HCMV) encodes for four viral GPCR homologues (vGPCRs), termed US27, US28, UL33, and UL78. Although HCMV-encoded GPCRs were first described in 1990, the pivotal functions of these viral receptor proteins were detected only recently. Here, we summarize seminal knowledge on the functions of herpesviral vGPCRs with a focus on novel roles of cytomegalovirus-encoded vGPCRs for viral spread and the regulation of latency.

Keywords: Cell signaling; Chemokine receptor; Cytomegalovirus; G protein-coupled receptor (GPCR); US28.

Publication types

  • Review

MeSH terms

  • Cytomegalovirus / growth & development*
  • Cytomegalovirus Infections / virology*
  • Host-Pathogen Interactions*
  • Humans
  • Receptors, G-Protein-Coupled / metabolism*
  • Viral Proteins / metabolism*
  • Virus Latency*
  • Virus Replication*


  • Receptors, G-Protein-Coupled
  • Viral Proteins