Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity

Sci China Life Sci. 2019 Oct;62(10):1409-1412. doi: 10.1007/s11427-018-9477-3. Epub 2019 Mar 12.

Authors

Juanjuan Feng¹, Mingjin Rao¹, Man Wang², Lin Liang², Zhi Chen¹, Xiufeng Pang¹, Weiqiang Lu¹, Zhenliang Sun³

Affiliations

¹ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
² Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, 201499, China.
³ Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, 201499, China. zhenliang6@126.com.

PMID: 30900168
DOI: 10.1007/s11427-018-9477-3

No abstract available

MeSH terms

3T3 Cells
Animals
Antineoplastic Agents, Alkylating / chemistry*
Antineoplastic Agents, Alkylating / metabolism
Apoptosis / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Diterpenes / chemistry*
Diterpenes / metabolism
Epoxy Compounds / chemistry
Epoxy Compounds / metabolism
Hedgehog Proteins / antagonists & inhibitors*
Humans
Mice
Pancreatic Neoplasms / drug therapy*
Phenanthrenes / chemistry*
Phenanthrenes / metabolism
Signal Transduction
Small Molecule Libraries / chemistry*

Substances

Antineoplastic Agents, Alkylating
Diterpenes
Epoxy Compounds
Hedgehog Proteins
Phenanthrenes
Small Molecule Libraries
triptolide