Gene-Environment Interaction in the Era of Precision Medicine

Cell. 2019 Mar 21;177(1):38-44. doi: 10.1016/j.cell.2019.03.004.


Innovative analytical frameworks are required to capture the complex gene-environment interactions. We investigate the insufficiency of commonly used models for disease genome analysis and suggest considering genetic interactions in complex diseases. For non-genetic factors, we study the emerging wearable technologies that have enabled quantification of physiological and environmental factors at an unprecedented breadth and depth. We propose a Bayesian framework to hierarchically model personalized gene-environmental interaction to enable precision health and medicine.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bayes Theorem
  • Epistasis, Genetic / genetics
  • Gene-Environment Interaction
  • Genome-Wide Association Study / methods
  • Humans
  • Multifactorial Inheritance / genetics
  • Precision Medicine / methods*
  • Precision Medicine / trends*
  • Wearable Electronic Devices / trends*