Global Genetic Networks and the Genotype-to-Phenotype Relationship

Cell. 2019 Mar 21;177(1):85-100. doi: 10.1016/j.cell.2019.01.033.


Genetic interactions identify combinations of genetic variants that impinge on phenotype. With whole-genome sequence information available for thousands of individuals within a species, a major outstanding issue concerns the interpretation of allelic combinations of genes underlying inherited traits. In this Review, we discuss how large-scale analyses in model systems have illuminated the general principles and phenotypic impact of genetic interactions. We focus on studies in budding yeast, including the mapping of a global genetic network. We emphasize how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Gene Frequency / genetics
  • Gene Regulatory Networks / genetics*
  • Gene Regulatory Networks / physiology*
  • Genetic Association Studies / trends*
  • Genetic Variation / genetics
  • Genotype
  • Humans
  • Models, Genetic
  • Phenotype
  • Quantitative Trait Loci / genetics
  • Saccharomyces cerevisiae / genetics