Sweetening the Therapeutic Pot for Type 2 Diabetes with Long Noncoding RNAs

Paige Dickson; Thomas Kodadek

doi:10.1016/j.chembiol.2019.02.022

Sweetening the Therapeutic Pot for Type 2 Diabetes with Long Noncoding RNAs

Cell Chem Biol. 2019 Mar 21;26(3):311-313. doi: 10.1016/j.chembiol.2019.02.022.

Authors

Paige Dickson¹, Thomas Kodadek²

Affiliations

¹ Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
² Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address: kodadek@scripps.edu.

PMID: 30901557
DOI: 10.1016/j.chembiol.2019.02.022

Abstract

Long noncoding RNAs (lncRNAs) have emerged as essential cellular regulators and potential disease targets. In this issue of Cell Chemical Biology, Shi et al. (2019) identify a cyclic peptide that results in restored glucose processing in type 2 diabetes mellitus (T2DM) patient derived adipocytes through stabilization of lncRNA GAS5.

Publication types

Comment

MeSH terms

Adipocytes
Diabetes Mellitus, Type 2*
Humans
RNA, Long Noncoding*

Substances

RNA, Long Noncoding