DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis

Psychiatry Res. 2019 Apr;274:391-394. doi: 10.1016/j.psychres.2019.02.068. Epub 2019 Feb 27.

Abstract

We investigated the role of DGCR2, a corticogenesis-related gene, on schizophrenia (SZ) and its subphenotypes, including brain morphology. A total of 221 SZ patients, 263 controls and 70 antipsychotic-naïve first episode of psychosis (FEP) were genotyped for 17 DGCR2 polymorphisms. While no association between DGCR2 polymorphisms and SZ was found, the missense variant rs2072123 was associated to left rostral anterior cingulate thickness, showing that DGCR2 seems not to be associated directly with the SZ but might be influencing the brain morphology. We also showed a DGCR2 downregulation in SZ patients when compared to controls and FEP.

Keywords: DGCR2; Neuroimaging; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Genotype
  • Gyrus Cinguli / pathology*
  • Humans
  • Male
  • Mutation, Missense
  • Platelet Glycoprotein GPIb-IX Complex / genetics*
  • Psychotic Disorders / genetics
  • Psychotic Disorders / pathology
  • Schizophrenia / genetics*
  • Schizophrenia / pathology*

Substances

  • Platelet Glycoprotein GPIb-IX Complex
  • adhesion receptor