[Vaccines for the treatment of non-small cell lung cancer]

Rev Mal Respir. 2019 Mar;36(3):415-425. doi: 10.1016/j.rmr.2018.12.003. Epub 2019 Mar 20.
[Article in French]


Antigen-specific immunotherapy also known as cancer vaccination offers a novel approach for the treatment of non-small cell lung cancer patients. It relies on specific priming of the immune system in order to provoke or increase adaptive antitumor immune response against the vaccine component. Several molecules have been developed in lung cancer, based on whole-tumor cells, dendritic cells, peptides, recombinant proteins, or viral vectors. The aim of this review is to describe the mechanism of action of these vaccines and the results of the main clinical studies.

Keywords: CBNPC; Cancer bronchique; Cancer vaccines; Immunotherapy; Immunothérapie; Lung cancer; NSCLC; Vaccins.

Publication types

  • Review

MeSH terms

  • Antigens, Neoplasm / immunology
  • Antigens, Neoplasm / therapeutic use
  • Cancer Vaccines / therapeutic use*
  • Carcinoma, Non-Small-Cell Lung / immunology
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Dendritic Cells / immunology
  • Dendritic Cells / transplantation
  • Drug Development / trends
  • Humans
  • Immunotherapy / methods*
  • Immunotherapy / trends
  • Lung Neoplasms / immunology
  • Lung Neoplasms / therapy*
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Lymphocytes, Tumor-Infiltrating / physiology


  • Antigens, Neoplasm
  • Cancer Vaccines