Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2019, 8761860

A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules


A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules

Alexandra Roi et al. Dis Markers.


Early diagnosis represents the target of contemporary medicine and has an important role in the prognosis and further treatment. Saliva is a biofluid that generated a high interest among researchers due to its multiple advantages over other body fluids. The multitude of components that can act as biomarkers influenced the existing technologies to develop protocols that could allow saliva to become the new noninvasive diagnostic method. Saliva as a diagnostic tool can bring substantial addition to the diagnostic armamentarium, providing important information about oral and general health. The diagnostic applications of saliva extended and had a rapid evolution due to the advancement in salivaomics. The present review summarizes the latest researches in saliva-related studies and explores the information and correlations that saliva can offer regarding the systemic and oral diseases, highlighting its great potential of diagnosis. It is expected that in the future specific guidelines and results regarding the salivary diagnostics are to be available, together with high-sensitivity and specificity tests for multiple systemic and oral diseases.

Similar articles

  • Saliva Diagnostics - Current Views and Directions
    KE Kaczor-Urbanowicz et al. Exp Biol Med (Maywood) 242 (5), 459-472. PMID 27903834. - Review
    In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. It …
  • Salivary Changes in Oral Mucosal Diseases
    Y Hassona et al. Periodontol 2000 70 (1), 111-27. PMID 26662486. - Review
    Saliva is a unique biological fluid that can be easily collected and analyzed with low cost and low morbidity. Therefore, there is a growing attention for using salivary …
  • Saliva in the Diagnosis of Diseases
    CZ Zhang et al. Int J Oral Sci 8 (3), 133-7. PMID 27585820. - Review
    Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advan …
  • [Application of Saliva in Disease Diagnosis]
    C Xingqun et al. Hua Xi Kou Qiang Yi Xue Za Zhi 34 (6), 647-653. PMID 28318170. - Review
  • Salivary Biomarkers for Clinical Applications
    L Zhang et al. Mol Diagn Ther 13 (4), 245-59. PMID 19712004. - Review
    For clinical applications such as monitoring health status, disease onset and progression, and treatment outcome, there are three necessary prerequisites: (i) a simple me …
See all similar articles


    1. Malathi N., Mythili S., Vasanthi H. R. Salivary diagnostics: a brief review. ISRN Dentistry. 2014;2014:8. doi: 10.1155/2014/158786.158786 - DOI - PMC - PubMed
    1. Lee Y. H., Wong D. T. Saliva: an emerging biofluid for early detection of diseases. American Journal of Dentistry. 2009;22(4):241–248. - PMC - PubMed
    1. Chiappin S., Antonelli G., Gatti R., De Palo E. F. Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clinica Chimica Acta. 2007;383(1-2):30–40. doi: 10.1016/j.cca.2007.04.011. - DOI - PubMed
    1. Nagler R. M., Hershkovich O., Lischinsky S., Diamond E., Reznick A. Z. Saliva analysis in the clinical setting: revisiting an underused diagnostic tool. Journal of Investigative Medicine. 2002;50(3):214–225. doi: 10.2310/6650.2002.33436. - DOI - PubMed
    1. Pfaffe T., Cooper-White J., Beyerlein P., Kostner K., Punyadeera C. Diagnostic potential of saliva: current state and future applications. Clinical Chemistry. 2011;57(5):675–687. doi: 10.1373/clinchem.2010.153767. - DOI - PubMed

MeSH terms