Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study

Int J Food Sci Nutr. 2019 Nov;70(7):901-908. doi: 10.1080/09637486.2019.1585763. Epub 2019 Mar 25.


The effect of chlorogenic acid-enriched green coffee bean extract (cGCE) intake on arterial stiffness was investigated using the cardio-ankle vascular index (CAVI) as a novel surrogate marker for predicting arteriosclerosis. A placebo-controlled double-blind pilot study was conducted with 16 healthy Japanese men. Subjects were divided into two groups and consumed beverages containing either cGCE or placebo daily for 2 weeks. The CAVI, the primary endpoint of the study, was evaluated at the beginning of the study and 2 weeks later. Endothelium-dependent flow-mediated dilation (FMD) and sympathetic nervous activity (SNA), which are thought to be related to the CAVI, were also measured. The CAVI change was significantly greater in the cGCE group than in the placebo group. In addition, FMD increased and SNA decreased in the cGCE group. These findings suggest that 2-week ingestion of cGCE may improve arterial stiffness as assessed by the CAVI.

Keywords: Arterial stiffness; chlorogenic acid; coffee.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Ankle
  • Ankle Brachial Index
  • Arteriosclerosis
  • Blood Pressure / drug effects
  • Body Mass Index
  • Cardiovascular Diseases
  • Chlorogenic Acid / pharmacology*
  • Coffee / chemistry*
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Plant Extracts / pharmacology*
  • Sympathetic Nervous System / drug effects
  • Vascular Stiffness / drug effects*


  • Coffee
  • Plant Extracts
  • Chlorogenic Acid