MOG antibody-associated encephalomyelitis/encephalitis

Mult Scler. 2019 Oct;25(11):1427-1433. doi: 10.1177/1352458519837705. Epub 2019 Mar 25.

Abstract

Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM). In this review, we discuss MOG-positive cases presenting with encephalitis, encephalopathy, or ADEM-like presentation based on recently published series.

Keywords: MOG antibody disease; MOG encephalomyelitis; MOG-EM; anti-MOG; myelin oligodendrocyte glycoprotein; optic neuritis; transverse myelitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Autoantibodies / immunology
  • Demyelinating Autoimmune Diseases, CNS / diagnosis
  • Demyelinating Autoimmune Diseases, CNS / immunology
  • Demyelinating Autoimmune Diseases, CNS / physiopathology*
  • Demyelinating Autoimmune Diseases, CNS / therapy
  • Disease Progression
  • Encephalitis / diagnosis
  • Encephalitis / immunology
  • Encephalitis / physiopathology*
  • Encephalitis / therapy
  • Encephalomyelitis / diagnosis
  • Encephalomyelitis / immunology
  • Encephalomyelitis / physiopathology*
  • Encephalomyelitis / therapy
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunologic Factors / therapeutic use
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging
  • Myelin-Oligodendrocyte Glycoprotein / immunology
  • Optic Neuritis / diagnosis
  • Optic Neuritis / immunology
  • Optic Neuritis / physiopathology
  • Optic Neuritis / therapy
  • Plasma Exchange

Substances

  • Adrenal Cortex Hormones
  • Autoantibodies
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Immunosuppressive Agents
  • Myelin-Oligodendrocyte Glycoprotein