Objective: To investigate the level of IgG antibody to varicella in the healthy population aged 1-19 years in Harbin, China.
Methods: Random sampling was performed to select 1 203 healthy individuals aged 1-19 years in Harbin. According to age, they were divided into ≥1 years group (n=240), ≥4 years group (n=396), ≥7 years group (n=364) and 14-19 years group (n=203). Enzyme-linked immunosorbent assay was used to measure the concentration of varicella-zoster virus (VZV)-IgG antibody in serum, and a concentration of VZV-IgG antibody of ≥100 mIU/mL was considered positive, suggesting that the subject had the ability to resist VZV infection.
Results: The overall positive rate of VZV-IgG antibody was 71.49% (860/1 203), and the concentration of VZV-IgG antibody was 447±17 mIU/mL. The concentration of VZV-IgG antibody tended to increase with age (P<0.05). The positive rate of VZV-IgG antibody in the urban population was significantly higher than that in the rural population (P<0.05). There was significant difference in the positive rate of VZV-IgG antibody between the populations with different doses of varicella vaccination (P<0.05), and the population with 2 doses of vaccination had the highest positive rate of VZV-IgG antibody. There was a significant difference in the concentration of VZV-IgG antibody between the populations with different medical histories (P<0.05), and the population with a past history of varicella had the highest concentration.
Conclusions: Among the healthy population aged 1-19 years in Harbin, there is a significant difference in the level of VZV-IgG antibody between the urban and rural populations, as well as between different age groups. Varicella vaccination should be strengthened in areas with a low vaccination rate and the population aged <14 years.
目的: 了解哈尔滨市1~19岁健康人群水痘IgG抗体水平,为完善水痘防控策略提供理论依据。
方法: 以随机抽样方法在全市范围内选取1 203名1~19岁健康调查对象,按年龄分为1岁~组(n=240)、4岁~组(n=396)、7岁~组(n=364)和14~19岁组(n=203)。采用酶联免疫吸附试验检测血清中水痘-带状疱疹病毒抗体(VZV-IgG)浓度,VZV-IgG浓度≥ 100 mIU/mL判定为阳性,表明调查对象具有抵抗水痘病毒感染的能力。
结果: VZV-IgG的抗体阳性率为71.49%(860/1 203),抗体浓度为447±17 mIU/mL。随着年龄增加,VZV-IgG抗体浓度呈上升趋势(P < 0.05);城市人群抗体阳性率高于农村(P < 0.05);不同剂次水痘疫苗免疫史人群VZV-IgG的抗体阳性率比较差异有统计学意义(P < 0.05),其中以2剂次免疫史人群的抗体阳性率最高。不同病史人群VZV-IgG的抗体浓度比较差异有统计学意义(P < 0.05),其中以患过水痘人群的抗体浓度最高。
结论: 哈尔滨市1~19岁健康人群水痘抗体水平存在城乡及年龄差异,需加强薄弱地区和14岁以下人群含水痘成分疫苗的接种工作。