Anatomy of congenital complete heart block and relation to maternal anti-Ro antibodies

Am J Cardiol. 1986 Aug 1;58(3):291-4. doi: 10.1016/0002-9149(86)90064-0.

Abstract

The anatomy of the conduction system was studied in 8 patients who had isolated congenital complete heart block. Atrial-axis discontinuity was seen in 7 hearts from children born to mothers with anti-Ro antibodies. The anticipated area of the atrioventricular node was occupied by fibrous and adipose tissue. The heart from the only child whose maternal serum was anti-Ro negative had nodoventricular discontinuity of the conduction system. This difference in anatomy may have etiologic significance.

MeSH terms

  • Antibodies / immunology*
  • Atrioventricular Node / pathology
  • Female
  • Heart Atria / pathology
  • Heart Block / congenital*
  • Heart Block / immunology
  • Heart Block / pathology
  • Heart Conduction System / pathology
  • Heart Ventricles / pathology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange
  • Myocardium / pathology
  • Pregnancy
  • Rh-Hr Blood-Group System / immunology*

Substances

  • Antibodies
  • Rh-Hr Blood-Group System