Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

Nat Med. 2019 May;25(5):734-737. doi: 10.1038/s41591-019-0403-9. Epub 2019 Mar 25.


Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoimmune Diseases / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Celiac Disease / classification
  • Celiac Disease / immunology*
  • Glutens / immunology
  • HLA-DQ Antigens / immunology
  • Humans
  • Immunophenotyping
  • Intestines / immunology
  • Lupus Erythematosus, Systemic / immunology
  • Scleroderma, Systemic / immunology
  • T-Lymphocyte Subsets / classification
  • T-Lymphocyte Subsets / immunology


  • HLA-DQ Antigens
  • Glutens