Abstract
Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens.
Keywords:
epimedokoreanin B; flavonoids; gingipains.
MeSH terms
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Adhesins, Bacterial / metabolism*
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Cysteine Endopeptidases / metabolism*
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Cysteine Proteinase Inhibitors / chemistry
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Cysteine Proteinase Inhibitors / pharmacology*
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Gingipain Cysteine Endopeptidases
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Humans
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Porphyromonas gingivalis / drug effects*
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Porphyromonas gingivalis / enzymology*
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Porphyromonas gingivalis / pathogenicity
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Virulence
Substances
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Adhesins, Bacterial
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Cysteine Proteinase Inhibitors
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Flavonoids
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Gingipain Cysteine Endopeptidases
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epimedokoreanin B
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Cysteine Endopeptidases