A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis

Biosci Biotechnol Biochem. 2019 Jul;83(7):1382-1384. doi: 10.1080/09168451.2019.1597615. Epub 2019 Mar 26.


Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens.

Keywords: epimedokoreanin B; flavonoids; gingipains.

MeSH terms

  • Adhesins, Bacterial / metabolism*
  • Cysteine Endopeptidases / metabolism*
  • Cysteine Proteinase Inhibitors / chemistry
  • Cysteine Proteinase Inhibitors / pharmacology*
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Gingipain Cysteine Endopeptidases
  • Humans
  • Porphyromonas gingivalis / drug effects*
  • Porphyromonas gingivalis / enzymology*
  • Porphyromonas gingivalis / pathogenicity
  • Virulence


  • Adhesins, Bacterial
  • Cysteine Proteinase Inhibitors
  • Flavonoids
  • Gingipain Cysteine Endopeptidases
  • epimedokoreanin B
  • Cysteine Endopeptidases