Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers

PLoS One. 2019 Mar 26;14(3):e0214285. doi: 10.1371/journal.pone.0214285. eCollection 2019.

Abstract

Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization-the immersion in an extreme socially depriving environment in humans-on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7-14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Psychological*
  • Child, Institutionalized
  • Child, Preschool
  • Cross-Sectional Studies
  • DNA Methylation
  • Epigenesis, Genetic*
  • Gene Regulatory Networks
  • Humans
  • Infant
  • Orphanages
  • Principal Component Analysis
  • Receptors, Glucocorticoid / genetics

Substances

  • NR3C1 protein, human
  • Receptors, Glucocorticoid

Grant support

Financial support of the study was provided by the Government of the Russian Federation; grant number 14.Z50.31.0027; PI: ELG. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.