Acceptance of antibiotic mixtures by infants and children

Eur J Clin Pharmacol. 1986;30(4):503-4. doi: 10.1007/BF00607970.


The acceptance by children of two pharmacologically identical phenoxymethyl-penicillin potassium and erythromycin ethylsuccinate mixtures, differing only in their flavouring agents, was compared in a randomised blind manner. The time a nurse required to give the drug to a child was recorded and a score of the acceptance was given by the nurse. The mean time to give erythromycin Brand 1 was 29 s (SD +/- 21, number of children = 20) and mean time to give Brand 2 it was 16 s (SD +/- 13, n = 18); the difference was significant (p less than 0.05). The mean scores were 2.9 (SD +/- 0.6) and 3.4 (SD +/- 0.5), difference -0.5 (p less than 0.025). The difference between the two penicillin products was not significant. The time required to give a medicine was a useful way to compare the effect of different flavouring mixtures on the acceptance of drugs by infants and children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Child
  • Child, Preschool
  • Double-Blind Method
  • Drug Compounding
  • Erythromycin / administration & dosage*
  • Flavoring Agents*
  • Humans
  • Infant
  • Penicillin V / administration & dosage*
  • Random Allocation
  • Taste*
  • Time Factors


  • Flavoring Agents
  • Erythromycin
  • Penicillin V