The human interleukin-2 receptor: analysis of structure and function

Immunol Rev. 1986 Aug;92:29-48. doi: 10.1111/j.1600-065x.1986.tb01492.x.

Abstract

Considerable information presently exists regarding the molecular, biochemical, and biological features of the human IL-2 receptor. The IL-2 receptor protein, multiple receptor mRNAs, and a single structural gene have now been identified. The important role of this receptor in normal T-cell growth is well established and its potential participation in B-cell growth and differentiation appreciated. The availability of cloned gene products for both the IL-2 receptor and IL-2 may permit the future development of novel biological agents capable of either augmenting or blunting the T-cell immune response. The intriguing interrelationship of HTLV-I and -II infection and altered IL-2 receptor expression is now being unraveled. However, the structural difference in high and low affinity receptors as well as the mechanism by which signals for T-cell growth are propagated through the high affinity receptor remain dominant, unanswered questions in the field.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes
  • Humans
  • Leukemia / physiopathology
  • Lymphocyte Activation
  • Lymphocytes / physiology*
  • RNA, Messenger / genetics
  • Receptors, Immunologic / physiology*
  • Receptors, Interleukin-2
  • Structure-Activity Relationship

Substances

  • Antibodies, Monoclonal
  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Interleukin-2