Expression of synaptophysin during postnatal development of the mouse brain

J Neurochem. 1986 Oct;47(4):1302-4. doi: 10.1111/j.1471-4159.1986.tb00754.x.


The expression of the synaptic vesicle membrane protein, synaptophysin, was analyzed during postnatal development of the mouse cerebrum using a quantitative immunoblotting procedure. From birth to adulthood, the relative contents of synaptophysin increased 80-fold, reaching a final level of 3.5 micrograms/mg of total protein. The time course of accumulation suggests that synaptophysin expression is correlated with synaptogenesis. Thus synaptophysin may be used as a reliable marker of nerve terminal differentiation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / growth & development*
  • Brain / metabolism
  • Collodion
  • Immunologic Techniques
  • Membrane Proteins / metabolism*
  • Mice
  • Synapses / physiology
  • Synaptic Membranes / physiology
  • Synaptophysin


  • Membrane Proteins
  • Synaptophysin
  • Collodion