The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome

Genet Med. 2019 Oct;21(10):2390-2400. doi: 10.1038/s41436-019-0489-y. Epub 2019 Mar 28.


Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.

Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.

Results: Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.

Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

Keywords: Lynch syndrome; endometrial cancer; guidance; screening; surveillance.

Publication types

  • Practice Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology
  • Colorectal Neoplasms, Hereditary Nonpolyposis / therapy*
  • Consensus
  • Early Detection of Cancer
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / therapy*
  • Europe
  • Female
  • Genital Neoplasms, Female / epidemiology
  • Genital Neoplasms, Female / therapy*
  • Humans
  • Mass Screening
  • North America
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / therapy