The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

Melanie M Ashton; Olivia M Dean; Adam J Walker; Chiara C Bortolasci; Chee H Ng; Malcolm Hopwood; Brian H Harvey; Marisa Möller; John J McGrath; Wolfgang Marx; Alyna Turner; Seetal Dodd; James G Scott; Jon-Paul Khoo; Ken Walder; Jerome Sarris; Michael Berk

doi:10.3389/fpsyt.2019.00115

The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

Front Psychiatry. 2019 Mar 13:10:115. doi: 10.3389/fpsyt.2019.00115. eCollection 2019.

Authors

Melanie M Ashton^{1

2

3}, Olivia M Dean^{1

2

4}, Adam J Walker¹, Chiara C Bortolasci⁵, Chee H Ng³, Malcolm Hopwood⁶, Brian H Harvey⁷, Marisa Möller⁷, John J McGrath^{8

9

10}, Wolfgang Marx¹, Alyna Turner^{1

4}, Seetal Dodd^{1

4

11}, James G Scott^{8

12

13}, Jon-Paul Khoo^{1

12}, Ken Walder⁵, Jerome Sarris^{3

14}, Michael Berk^{1

2

4

11

15}

Affiliations

¹ IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.
² Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
³ Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, Australia.
⁴ Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
⁵ Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, VIC, Australia.
⁶ Professorial Psychiatry Unit, Albert Road Clinic, University of Melbourne, Melbourne, VIC, Australia.
⁷ Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South Africa.
⁸ Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
⁹ Queensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.
¹⁰ National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
¹¹ Centre of Youth Mental Health, University of Melbourne, Parkville, VIC, Australia.
¹² Faculty of Medicine, The University of Queensland, Herston, QLD, Australia.
¹³ Metro North Mental Health, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
¹⁴ NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
¹⁵ Orygen Youth Health Research Centre, Parkville, VIC, Australia.

Abstract

New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

Keywords: bipolar disorder; inflammation; mangosteen pericarp; mitochondria; oxidative stress; psychiatry; schizophrenia.

Publication types

Review