Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract

Microbiol Immunol. 2019 May;63(5):155-163. doi: 10.1111/1348-0421.12680. Epub 2019 May 15.


Gut microbes symbiotically colonize the gastrointestinal (GI) tract, interacting with each other and their host to maintain GI tract homeostasis. Recent reports have shown that gut microbes help protect the gut from colonization by pathogenic microbes. Here, we report that commensal microbes prevent colonization of the GI tract by the pathogenic fungus, Candida albicans. Wild-type specific pathogen-free (SPF) mice are resistant to C. albicans colonization of the GI tract. However, administering certain antibiotics to SPF mice enables C. albicans colonization. Quantitative kinetics of commensal bacteria are inversely correlated with the number of C. albicans in the gut. Here, we provide further evidence that transplantation of fecal microbiota is effective in preventing Candida colonization of the GI tract. These data demonstrate the importance of commensal bacteria as a barrier for the GI tract surface and highlight the potential clinical applications of commensal bacteria in preventing pathogenic fungal infections.

Keywords: Candida albicans; antibiotics; commensal bacteria; fecal microbiota transplantation.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • Bacteria* / drug effects
  • Candida albicans / pathogenicity*
  • Candidiasis / prevention & control*
  • Fecal Microbiota Transplantation*
  • Gastrointestinal Microbiome* / drug effects
  • Gastrointestinal Tract / microbiology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Symbiosis


  • Anti-Bacterial Agents