Treatment of gynecological malignancies: long-term follow-up of health-related quality of life and healthcare costs

J Comp Eff Res. 2019 May;8(7):475-486. doi: 10.2217/cer-2018-0125. Epub 2019 Mar 29.


Aim: To assess long-term health-related quality of life (HRQoL) and treatment-related costs in gynecological cancer patients, and to compare HRQoL between cancer types and to age-standardized general female population. Materials & methods: A prospective 8-10-year follow-up of 218 patients treated in Helsinki University Hospital in 2002-2004. Results: The most common malignancies were uterine, ovarian and cervical cancers. The mean HRQoL scores were 0.880 (baseline), 0.885 (6 months) and 0.884 for survivors in the end of the study. Depression, vitality and sexual activity were impaired at baseline but improved during follow-up. Total secondary healthcare costs during the follow-up averaged EUR 41342. Conclusion: The long-term HRQoL of surviving gynecological cancer patients was good and similar to that of age-standardized general female population.

Keywords: cancer; costs; gynecology; health-related quality of life; treatment.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Depression / epidemiology
  • Female
  • Finland
  • Follow-Up Studies
  • Genital Neoplasms, Female / economics*
  • Genital Neoplasms, Female / psychology
  • Genital Neoplasms, Female / therapy*
  • Health Expenditures / statistics & numerical data*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Sexual Behavior
  • Survivors / psychology
  • Survivors / statistics & numerical data*