Thyrotoxicosis: Diagnosis and Management

Mayo Clin Proc. 2019 Jun;94(6):1048-1064. doi: 10.1016/j.mayocp.2018.10.011. Epub 2019 Mar 25.


Thyrotoxicosis is the clinical manifestation of excess thyroid hormone action at the tissue level due to inappropriately high circulating thyroid hormone concentrations. Hyperthyroidism, a subset of thyrotoxicosis, refers specifically to excess thyroid hormone synthesis and secretion by the thyroid gland. We performed a review of the literature on these topics utilizing published data in PubMed and MEDLINE. In this review, we discuss the more common etiologies of thyrotoxicosis, focusing on the current approach to diagnosis and management, new trends in those directions, and potential upcoming changes in the field.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Glucocorticoids / therapeutic use*
  • Humans
  • Propranolol / therapeutic use*
  • Thyroid Gland / surgery*
  • Thyrotoxicosis / diagnosis*
  • Thyrotoxicosis / drug therapy*


  • Adrenergic beta-Antagonists
  • Glucocorticoids
  • Propranolol