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. 2019;57(1):23-27.
doi: 10.5603/FHC.a2019.0003. Epub 2019 Mar 29.

Immunohistochemical Demonstration of LH/CG Receptors in Non-Neoplastic Human Adrenal Cortex and Adrenocortical Tumors

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Immunohistochemical Demonstration of LH/CG Receptors in Non-Neoplastic Human Adrenal Cortex and Adrenocortical Tumors

Piotr Korol et al. Folia Histochem Cytobiol. .
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Abstract

Introduction: Numerous data indicate that luteinizing hormone and/or chorionic gonadotropin (LH/CG) exert direct actions on the adrenal cortex and are involved in the adrenal pathology. However, the immunohistochemical studies on the expression of LH/CG receptors (LH/CGR) in the human adrenal cortex and in the adrenocortical tumors are scarce.

Material and methods: Paraffin sections of samples of 6 human non-neoplastic adrenal cortex and 25 adrenocortical tumors were immunostained with anti-LH/CGR polyclonal antibody.

Results: All zones of the human non-neoplastic adrenal cortex present a positive immunoreaction with anti-LH/CGR antibody showing the strongest reaction in cell membranes. The LH/CGR immunostaining in the vast majority of hormonally non-functioning adenomas and in all hormone-secreting adenomas does not differ from the non-neoplastic adrenal cortex. In contrast to non-neoplastic adrenal cortex and benign adenomas, in adrenocortical cancers the immunostaining with anti-LH/CGR antibody behaves differently. The immunopositive material is almost totally filling the cytoplasm of the cells but the immunopositivity of cell membranes is weak or lacking.

Conclusions: The data presented in our study show that the expression of LH/CGR in adrenocortical tumors is not ectopic but eutopic. The immunohistochemical examination of LH/CGR may be useful in the differentiation between benign and malignant lesions in the adrenal cortex. Moreover, the loss of membrane localization of LH/CGR in adrenocortical cancer suggests the alteration of receptors' function.

Keywords: adrenal cortex; adrenocortical adenomas; adrenocortical cancer; luteinizing hormone/chorionic gonadotropin receptor.

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