Nutrigenetics of Blood Cholesterol Concentrations: Towards Personalized Nutrition

Curr Cardiol Rep. 2019 Mar 29;21(5):38. doi: 10.1007/s11886-019-1124-x.


Purpose of the review: To summarize achievements made in the field of nutrigenetics to personalized nutrition. Moreover, the limitations and challenges observed to enable clinical utilization are discussed.

Recent findings: Currently, with the availability of low-cost genetic testing and new bioinformatics tools, significant developments have occurred to allow issues inherent to the highly complex nature of genetic data to be tackled. Moreover, new statistical methods have uncovered combinatory patterns of SNPs that collectively explain the high interindividual variability in response to dietary interventions. Yet, the application of these results to personalized dietary recommendations is not straightforward. Data from gene-nutrient interaction studies have provided evidence to understand the inter-individual variation differences in blood cholesterol responses. A need exists for guidelines and regulations in order to apply nutrigenetics to personalized nutrition. Moreover, a multisystem approach including genetics, microbiome and environment is needed to achieve possible practical applications.

Keywords: Cardiovascular disease; Gene-nutrient interactions; Genetic variant; Lipid; Single nucleotide polymorphisms.

Publication types

  • Review

MeSH terms

  • Cholesterol / blood*
  • Dyslipidemias / diet therapy*
  • Dyslipidemias / genetics*
  • Genetic Testing
  • Humans
  • Nutrigenomics*
  • Polymorphism, Single Nucleotide
  • Precision Medicine*


  • Cholesterol