The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice

Cell. 1986 Oct 10;47(1):11-8. doi: 10.1016/0092-8674(86)90361-2.

Abstract

Transgenic mice bearing a c-myc oncogene subjugated to the lymphoid-specific immunoglobulin heavy chain enhancer (E mu) develop clonal B lymphoid malignancies, but most young E mu-myc mice lack malignant clones. Their prelymphomatous state has allowed us to examine how constitutive c-myc expression influences B cell development. We find that early stages are overrepresented, even before birth. Pre-B cells of polyclonal origin increase greatly, while B cells develop in reduced number. Both the pre-B and the B cells appear to be in an active state, since they are larger than normal and a greater fraction are in the cell cycle. Enforced myc expression has thus favored proliferation over maturation. Hence, a normal function of c-myc may be to regulate differentiation as well as to promote cell cycling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / pathology*
  • Cell Differentiation
  • Enhancer Elements, Genetic*
  • Gene Expression Regulation
  • Genes, Regulator*
  • Hematopoiesis*
  • Hematopoietic Stem Cells / pathology
  • Histocompatibility Antigens Class II / analysis
  • Immunoglobulin mu-Chains / genetics*
  • Lymphoma / genetics*
  • Lymphoma / pathology
  • Mice
  • Oncogenes*
  • Precancerous Conditions / pathology
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-myc
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / physiology

Substances

  • Histocompatibility Antigens Class II
  • Immunoglobulin mu-Chains
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myc
  • Recombinant Fusion Proteins