Visit-to-visit Blood Pressure Variability and Arterial Stiffness: Which Came First: The Chicken or the Egg?

Curr Pharm Des. 2019;25(6):685-692. doi: 10.2174/1381612825666190329122024.


Earlier studies have shown that visit-to-visit blood pressure (BP) variability (VVV) served as a significant independent risk factor of stroke, specifically, in the high-risk elderly of cardiovascular disease (CVD). Although the mechanism is not clearly understood, arterial remodeling such as carotid artery, coronary artery and large aortic artery would be a strong moderator in the relationship between VVV and CVD incidence. Recent studies have provided evidence that VVV predicted the progression of arterial stiffness. While the class of antihypertensive agents is suggested to be an important determinant of VVV, long-acting calcium channel blockers use (CCBs) is associated with the reduction of VVV, and thus, is suggested to decrease the arterial stiffness. Specifically, the relationship between VVV and coronary arterial remodeling has never been reviewed until now. This article summarizes the recent literature on these topics. In the elderly hypertensives, strict BP control using CCBs could play a pivotal role in suppressing arterial stiffening via VVV reduction.

Keywords: Hypertension; arterial stiffness; artery remodeling; coronary artery; intima-media thickness; visit-to-visit blood pressure variability..

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / pharmacology
  • Blood Pressure Determination
  • Blood Pressure*
  • Calcium Channel Blockers / pharmacology
  • Humans
  • Hypertension / drug therapy
  • Vascular Stiffness*


  • Antihypertensive Agents
  • Calcium Channel Blockers