[Pathological consequences of excess of interferon in vivo]

Med Sci (Paris). 2019 Mar;35(3):232-235. doi: 10.1051/medsci/2019037. Epub 2019 Apr 1.
[Article in French]


In this brief review, the authors present a history of the different aspects of the scientific puzzle leading from pioneer animal studies and astute clinical experimental observations to a mature appreciation of the deleterious role of excess of a type I interferon in human pathology.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / adverse effects
  • Antiviral Agents / metabolism
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immune System Diseases / etiology
  • Interferon Type I / adverse effects*
  • Interferon Type I / physiology*
  • Lupus Erythematosus, Systemic / etiology
  • Lupus Erythematosus, Systemic / immunology
  • Mice
  • Models, Animal


  • Antiviral Agents
  • Interferon Type I