Successful treatment with pollen extract of hematospermia in patients with xanthogranolomatous prostatitis

Arch Ital Urol Androl. 2019 Mar 29;91(1):22-24. doi: 10.4081/aiua.2019.1.22.


Introduction: The aim of this study was to report our experience in the management of hematospermia observed in 16 patients suffering from xanthogranulomatous prostatitis.

Methods: Recurrent episodes of hematospermia were the onset symptom in all patients, and in 25% of patients it was combined with fever. All patients reported PSA value elevation and the digital rectal examination (DRE) revealed an increase of the gland size and of its consistency in all cases. In all patients, the hematospermia was treated with the oral administration of two tablets of pollen extract in a single (1 g) dose daily for 30 days.

Results: Sixteen patients were observed between 2008 and 2016, referring hematospermia, progressive lower urinary tract symptoms (LUTS), and serum PSA level increase. To exclude the prostate cancer presence all patients were submitted to transperineal TRUS guided biopsy. In all the patients complete resolution of hematospermia was achieved treatment with pollen extract. All patients were subsequently treated for LUTS (alpha-adrenergic blockers), but none reported any significant improvement of symptoms. Basing on these pieces of evidence, after 90 days of alpha-blockers therapy, all patients underwent bipolar TURP. Histological examination of resected prostatic tissue revealed in all patients the diagnosis of xanthogranulomatous prostatitis.

Conclusions: Patients with xanthogranulomatous prostatitis especially experience irritative symptoms, sometimes combined with fever or hematospermia. Hematospermia as the onset symptom has not been reported so far. The administration of the pollen extract for 30 days was associated with a complete resolution of hematospermia.

MeSH terms

  • Adrenergic alpha-Antagonists / administration & dosage
  • Biopsy
  • Digital Rectal Examination
  • Fever / etiology
  • Hemospermia / diagnosis
  • Hemospermia / drug therapy*
  • Hemospermia / etiology
  • Humans
  • Lower Urinary Tract Symptoms / etiology
  • Lower Urinary Tract Symptoms / therapy
  • Male
  • Plant Extracts / administration & dosage*
  • Pollen / chemistry*
  • Prostate-Specific Antigen / blood
  • Prostatitis / complications
  • Prostatitis / diagnosis
  • Prostatitis / therapy*
  • Transurethral Resection of Prostate / methods


  • Adrenergic alpha-Antagonists
  • Plant Extracts
  • Prostate-Specific Antigen