Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

J Clin Oncol. 2019 May 10;37(14):1228-1263. doi: 10.1200/JCO.18.02096. Epub 2019 Apr 1.


Purpose: To provide evidence-based recommendations on the treatment of multiple myeloma to practicing physicians and others.

Methods: ASCO and Cancer Care Ontario convened an Expert Panel of medical oncology, surgery, radiation oncology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and some phase II studies published from 2005 through 2018. Outcomes of interest included survival, progression-free survival, response rate, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.

Results: The literature search identified 124 relevant studies to inform the evidence base for this guideline.

Recommendations: Evidence-based recommendations were developed for patients with multiple myeloma who are transplantation eligible and those who are ineligible and for patients with relapsed or refractory disease.

Publication types

  • Practice Guideline

MeSH terms

  • Clinical Trials, Phase II as Topic
  • Humans
  • Medical Oncology / methods
  • Medical Oncology / standards*
  • Multiple Myeloma / therapy*
  • Randomized Controlled Trials as Topic
  • Systematic Reviews as Topic