Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 16 (3), 199-205

The Development of Evidence-Based Guideline for Diagnosis and Management of Headache in Korea


The Development of Evidence-Based Guideline for Diagnosis and Management of Headache in Korea

Sun Mi Kim et al. Psychiatry Investig.


Objective: We aimed to develop the clinical guideline for headache by the systematic review and synthesis of existing evidence-based guidelines. The purpose of developing the guideline was to improve the appropriateness of diagnosis and treatment of headache disorder, and consequently, to improve patients' pain control and quality of life. The guideline broadly covers the differential diagnosis and treatment of tension-type headache, migraine, cluster headache, and medication-overuse headache.

Methods: This is a methodological study based on the ADAPTE methodology, including a systematic review of the literature, quality assessment of the guidelines using the Appraisal of Clinical Guidelines for REsearch & Evaluation II (AGREE II) Instrument, as well as an external review using a Delphi technique. The inclusion criteria for systematic search were as follows: topic-relevant, up-to-date guidelines including evidence from within 5 years, evidence-based guidelines, guidelines written in English or Korean, and guidelines issued by academic institutions or government agencies.

Results: We selected five guidelines and conducted their quality assessment using the AGREE II Instrument. As a result, one guideline was found to be eligible for adaptation. For 13 key questions, a total of 39 recommendations were proposed with the grading system and revised using the nominal group technique.

Conclusion: Recommendations should be applied to actual clinical sites to achieve the ultimate goal of this guideline; therefore, follow-up activities, such as monitoring of guideline usage and assessment of applicability of the recommendations, should be performed in the future. Further assessment of the effectiveness of the guideline in Korea is needed.

Keywords: Cluster headache; Guideline; Headache; Medication-overuse headache; Migraine; Tension-type headache.


Figure 1.
Figure 1.
Three phases of the ADAPTE process.
Figure 2.
Figure 2.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram.

Similar articles

See all similar articles


    1. Steiner TJ, Stovner LJ, Katsarava Z, Lainez JM, Lampl C, Lanteri-Minet M, et al. The impact of headache in Europe: principal results of the Eurolight project. J Headache Pain. 2014;15:31. - PMC - PubMed
    1. Healthcare Bigdata Hub. Available at: Accessed November 1, 2018.
    1. Headache Classification Committee of the International Headache Society (IHS) The international classification of headache disorders, 3rd edition (beta version) Cephalalgia. 2013;33:629–808. - PubMed
    1. Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27:193–210. - PubMed
    1. Sharma TL. Common primary and secondary causes of headache in the elderly. Headache. 2018;58:479–484. - PubMed