Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease

Curr Med Res Opin. 2019 Sep;35(9):1529-1534. doi: 10.1080/03007995.2019.1601455. Epub 2019 Apr 15.


Prediabetes is defined as a state of abnormal glucose homeostasis where blood glucose levels are elevated above those considered normal, but not as high as those required for a diagnosis of diabetes. As a condition intermediate between normal glucose homeostasis and the pathological condition of diabetes, the characterization of prediabetes as a distinct pathogenic condition is controversial. Emerging evidence suggests that the condition of prediabetes is associated with pathophysiological changes in several tissues and organs, which would support its recognition as a distinct pathological entity; the recent inclusion of prediabetes and associated billable conditions in the most recent ICD-10 codes provides additional credence to this position. This minireview summarizes our understanding of prediabetes and provides evidence that it should be considered a distinct and important clinical entity.

Keywords: ICD-10 codes; Prediabetes; management; pathophysiology; prevalence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Glucose / analysis
  • Cost of Illness*
  • Humans
  • Life Style
  • Prediabetic State / complications
  • Prediabetic State / drug therapy
  • Prediabetic State / epidemiology*
  • Prevalence


  • Blood Glucose