The impact of cystic fibrosis-related diabetes on health-related quality of life

J Cyst Fibros. 2019 Sep;18(5):734-736. doi: 10.1016/j.jcf.2019.03.007. Epub 2019 Mar 29.


Cystic fibrosis-related diabetes (CFRD) is a well-known comorbidity among the CF population. To investigate whether CFRD impacts health-related quality of life (HRQoL), domain scores from the Cystic Fibrosis Questionnaire-Revised for adolescents and adults over 14 years old (CFQ-R 14+) were compared between CF individuals with CFRD on insulin, CFRD not on insulin, impaired glucose tolerance, and normal blood glucose tolerance. The median score for the Treatment Burden domain was significantly worse for individuals with CFRD on insulin (p < 0.001) compared to the other diagnostic groups, and this association remained significant following adjustment for confounding variables. In conclusion, the additional requirement for insulin significantly contributes to treatment burden in adults with CFRD and therefore novel strategies to reduce treatment burden for this group are urgently needed.

Keywords: CFQ-R teen/adult version; Cystic fibrosis-related diabetes; Health-related quality of life; Insulin.

MeSH terms

  • Adolescent
  • Cost of Illness*
  • Cystic Fibrosis* / complications
  • Cystic Fibrosis* / genetics
  • Cystic Fibrosis* / physiopathology
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / psychology*
  • Diabetes Mellitus / therapy
  • Female
  • Glucose Intolerance* / diagnosis
  • Glucose Intolerance* / etiology
  • Glucose Tolerance Test / methods
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use*
  • Male
  • Needs Assessment
  • Quality of Life*
  • Surveys and Questionnaires


  • Hypoglycemic Agents
  • Insulin