The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review

J Cutan Med Surg. 2019 Jul/Aug;23(4):428-435. doi: 10.1177/1203475419836435. Epub 2019 Apr 2.


Acrodermatitis continua of Hallopeau is a rare subtype of pustular psoriasis that presents as a sterile, pustular eruption commonly in the finger tips and toes. This disease inflicts both the skin and nail bed, and causes severe disfigurement of the distal phalanges. Because it is a variant of pustular psoriasis, acrodermatitis continua of Hallopeau is commonly managed with antipsoriatic medications. Common approaches to treatment include topical therapy (corticosteroids, vitamin D analogs, and calcineurin inhibitors), systemic therapy, and in more severe cases, biologic therapy. This review will discuss how acrodermatitis continua of Hallopeau is diagnosed and how it is managed, with a particular emphasis on the use of biologics.

Keywords: IL-12/23; IL-17; acrodermatitis continua of Hallopeau; anti-TNF; biologic therapy; pustular psoriasis.

Publication types

  • Review

MeSH terms

  • Acrodermatitis / diagnosis
  • Acrodermatitis / drug therapy*
  • Biological Products / therapeutic use*
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Interleukin-1 / antagonists & inhibitors
  • Interleukin-17 / antagonists & inhibitors
  • Interleukin-23 / antagonists & inhibitors
  • Psoriasis / diagnosis
  • Psoriasis / drug therapy*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*


  • Biological Products
  • Dermatologic Agents
  • Interleukin-1
  • Interleukin-17
  • Interleukin-23
  • Tumor Necrosis Factor-alpha